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Non-Hodgkin's Lymphoma (NHL) is a primary malignancy of lymphocytes that can be derived from B lymphocytes, T lymphocytes. Vitamin C plays a role as an antioxidant in the body. This study was to find out the effect of vitamin C administration on LDH serum levels and quality of life in NHL patients at RSMH Palembang. This study was a pilot study with open clinical trials, conducted from February 2021 to May 2021. There were 15 research subjects (age18-60 years) given vitamin C supplementation 2 grams per day for 8 weeks. Before and after treatment was examined LDH levels, serum vitamin C, fill out the FFQ questionnaire (intake of vitamin C) and EORTC C30 questionnaire (quality of life). Obtained a decrease in LDH levels between before and after treatment in the low grade group (p =0.008) and in the high grade group (p= 0.000). Obtained improvement of quality of life between before and after treatment in the low grade group (p <0.05). A strong negative correlation was obtained in the high grade group between vitamin C levels and LDH levels before treatment (r= -0.75 p = 0.031) and after treatment (r= -0.819 p = 0.013). In the high grade group after treatment there was a strong positive correlation between vitamin C nutrisurvey with function scale (r = 0.790 p = 0.02) and strong negative correlation with symptom scale (r = -0.74 p = 0.03). Vitamin C supplementation decrease LDH serum levels in all clinical stages of NHL patients and improve quality of life and influence the correlation between vitamin C levels and the scale component of quality of life symptoms in advanced or high grade group of NHL patients in RSMH Palembang.


LDH non lymphoma–hodgkin's quality of life vitamin c

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Roezin, S. F., Syahrir, M., Anastasia, M., & Bahar, E. (2021). The effect of vitamin c supplementation on serum LDH levels and quality of life of non-hodgkin lymphoma patients. Sriwijaya Journal of Medicine, 4(2), 123-130.