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Abstract

The Chronic Renal Insufficiency Cohort (CRIC) study showed that 86% of CKD subjects had inflammation. The number of longitudinal studies reported that there was increasing inflammation by measuring interleukin-6 (IL-6) in PD patients at both systemic and intraperitoneal levels. Garlic and its components have anti-inflammatory and antioxidant activity. Anti-inflammatory effect of garlic extract, by inhibiting the activation of the pro-inflammatory pathway as well as inhibiting macrophage activation and its antioxidant effects and inhibiting pro-oxidant enzymes. This study was a crossover randomized placebo controlled double blind trial. The subjects of the study were 20 CKD stage 5 patients using CAPD, divided randomly into 2 groups, namely the group that received 800 mg of garlic extract per day (2x400 mg) for 8 weeks and the group that received a placebo, then a wash out period of 2 weeks was carried out. and after that the two groups were given alternating treatment. Each group measured the levels of serum IL-6, IL-6 dialysate and net ultrafiltration before and after treatment. It was found that serum IL-6 levels before and after garlic extract were 7.10 ± 2.30 pg / ml and 5.00 ± 3.00 pg / ml with p = 0.005. The IL-6 dialysate levels before and after garlic extract administration were 39.20 ± 2.10 pg / ml and 33.20 ± 7.80 pg / ml with p = 0.000. It was concluded that the decrease in serum IL-6 and dialysate levels after garlic extract in CKD stage V patients using CAPD at RSMH Palembang.

Keywords

CAPD garlic extract interleukin-6 dialysate serum interleukin-6

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How to Cite
Kendenan, M., Ali, Z., Kurniati, N., & Saleh, I. (2021). The effectiveness of garlic extract to the reduction of interleukin-6 serum and dialysis continous ambulatory patients peritoneal dialysis.: indonesia . Sriwijaya Journal of Medicine, 4(2), 131-137. https://doi.org/10.32539/SJM.v4i2.281