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Background: Primary CNS Lymphoma (PCNSL) is rare cancer from the brain or spinal cord lymphatic tissue. The incidence increased in patients over 60 years, with an incidence rate of 0.5/100,000 per year. PCNSL associated with poor survival. The aim of the study was to determine the incidence of Brain Malignant Lymphoma based on age, gender, symptoms, imaging modalities, HIV examination, and histopathological results at dr. Kariadi Semarang.

Methods: This is a retrospective descriptive study. We collected brain malignant lymphoma patient’s medical records who came to the ER and the Neurosurgery Polyclinic of Dr. Kariadi Semarang from period January 2016-December 2018.

Results: There were 1,012 brain tumor patients, 6 patients were brain malignant lymphoma with the highest prevalence in the age range of 45-65 years (5 patients) and 66.67% male. The most common symptom was blurred vision 23.07%. The imaging modalities showed lesions on: right parietal lobe 14.29%, sella region 14.29%, parasella region 14.29%, cerebellum 14.29%, IV ventricle 14.29%, vertebrae sacrum 2-5 14.29 %, and the fronto-temporo-parietal region 14.29%. No HIV test data were obtained. According to histopathology, Diffuse large B cell Lymphoma Malignant non Germinal Center (DLBCL) and High grade, B cell Non Hodgkin Lymphoma (small type) each were 33.33%.

Conclusions: The prevalence of malignant brain lymphoma cases was highest in the 45–65 year age group and male, with blurred vision. Most of the results of imaging modalities show an even distribution of brain malignant lymphomas and generally do not do HIV testing. The most common histopathological diagnosis was DLBCL.


DLBCL Non Hodgkin Lymphoma Brain Malignant Lymphoma

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How to Cite
Kemara, S. A., & Krisna Tsaniadi Prihastomo. (2021). Malignant Brain Lymphoma Based on Age, Gender, Symptoms, Imaging Modality, Hiv Examination, And Histopathology at Dr. Kariadi Central General Hospital Semarang From January 2016 to December 2018. Biomedical Journal of Indonesia, 7(3), 481-487.